The best travel itinerary for Rome will depend on your personal interests and the amount of time you have in the city. Here's a sample itinerary that covers many of Rome's must-see destinations:
Day 1: Arrival and explore the Vatican City, visit St. Peter's Basilica and the Vatican Museums.
Day 2: Walk to the Colosseum and explore the Roman Forum, Palatine Hill and Circus Maximus.
Day 3: Visit the Pantheon, Piazza Navona and the Trevi Fountain.
Day 4: Explore the Trastevere neighborhood, visit the Villa Farnesina, and enjoy a gelato.
Day 5: Visit the Capitoline Museums and the Campidoglio, then walk to the Jewish Ghetto and explore the market.
Day 6: Visit the Borghese Gallery, explore the Villa Borghese park and see the Spanish Steps.
Day 7: Visit the Catacombs, the Appian Way and the Aqueducts Park.
This itinerary assumes 7 full days in Rome, and can be modified to fit your specific needs and interests. Also, be mindful of crowds, museum closures, and other factors that may impact your travel plans.